What is PRP?
Platelet-rich plasma (PRP) therapy is a very important player in regenerative medicine. The PRP is "made" from blood drawn from the patient and undergoes a process to isolate the platelets and the many growth factor that they contain. These growth factors are delivered to the brain through olfactory nerve and cribriform plate which is accessed via intranasal atomization of patient's PRP.
Growth factors found in PRP that are indicated in helping those that suffer from TBI/concussions:
Basic fibroblast growth factor (bFGF)
Osteogenesis and angiogenesis
Transforming growth Factor TGF-β
One of the most abundant GFs released from PRP, is demonstrated to promote tendon healing in the absence of scar formation. Therefore, it is considered as a good candidate to reproduce a tendon-bone insertion site.
Vascular endothelial growth factor (VEGF)
Are a family of signaling proteins that function to stimulate both angiogenesis and vasculogenesis through a tyrosine kinase receptor-mediated signaling cascade
Platelet derived growth factor (PDGF)
Has been shown to improve healing in bone repairs models. Platelet derived growth factor (PDGF), could be used after a rotator cuff tear, to induce proliferation and synthesis of tenocytes with appropriate ECM proteins.
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